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Table 3 Concordances between single methods and combined gene/protein methods

From: The validation of a novel method combining both HER2 immunohistochemistry and HER2 dual-colour silver in situ hybridization on one slide for gastric carcinoma testing

Single vs. combination

Concordance

Kappa-Coefficient к

Agreement Altmann [[15]]

SISH amplified

100 %

1

Very good

IHC score 0

100 %

1

Very good

IHC score 1+

98.96%

0.947

Very good

IHC score 2+

95.83%

0.728

Good

IHC score 3+

96.88%

0.825

Very good

  1. Abbreviations: IHC immunohistochemistry, SISH silver in situ hybridization.