Table 1 Patient´s characteristics and HER2 positivity by subgroups
| Â | Total n=96 (%) | Positivity* (IHC 3+ or SISH +) single n(%) | Positivity* (IHC 3+ or SISH +) combi n(%) |
|---|---|---|---|
Sex | Â | Â | Â |
Female | 27 (28.1) | 2 (7.4) | 1 (3.7) |
Male | 65 (67.7) | 11 (16.9) | 11 (16.9) |
Unknown | 4 (4.2) | 3 (75.0) | 3 (75.0) |
Age | 18-94 yrs (Median 69) | Â | Â |
≥ 65 | 68 (70.8) | 12 (17.6) | 11 (16.2) |
< 65 | 28 (29.2) | 4 (14.3) | 4 (14.3) |
Primary tumor location | Â | Â | Â |
Mid to distal stomach | 48 (50.0) | 5 (10.4) | 4 (8.3) |
GEJ | 44 (45.8) | 8 (18.2) | 8 (18.2) |
Not specified | 4 (4.2) | 3 (75.0) | 3 (75.0) |
Lauren classification | Â | Â | Â |
Diffuse | 27 (28.1) | 3 (11.1) | 2 (7.4) |
Mixed | 4 (4.2) | 1 (25.0) | 1 (25.0) |
Intestinal | 65 (67.7) | 12 (18.5) | 12 (18.5) |
Biopsy/resection | Â | Â | Â |
Biopsy | 68 (70.8) | 10 (14.7) | 9 (13.2) |
Resection | 28 (29.2) | 6 (21.4) | 6 (21.4) |
T stage ( n =28) | Â | Â | Â |
T 1 | 4 (14.3) | 0 | 0 |
T 2 | 8 (28.6) | 2 (25.0) | 2 (25.0) |
T 3 | 14 (50.0) | 4 (28.6) | 4 (28.6) |
T 4 | 2 (7.1) | 0 | 0 |
N stage ( n =28) | Â | Â | Â |
N + | 24 (85.7) | 5 (20.8) | 5 (28.8) |
N - | 4 (14.3) | 1 (25.0) | 1 (25.0) |
M stage ( n =28) | Â | Â | Â |
M + | 5 (17.9) | 1 (20.0) | 1 (20.0) |
M - | 18 (64.3) | 3 (16.7) | 3 (16.7) |
Mx | 5 (17.9) | 2 (40.0) | 2 (40.0) |
Grading | Â | Â | Â |
G2 | 38 (39.6) | 6 (15.8) | 6 (15.8) |
G2-3 | 10 (10.4) | 2 (20.0) | 2 (20.0) |
G3 | 48 (50.0) | 8 (16.7) | 7 (14.6) |