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Table 1 Expression of ER-α36 in cancers

From: The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors

Tumor type (*) Study Kind/num. of analyzed samples Method (**) Potential clinical significant
BC Lee, et al.[16] 37 BC tissues IHC/WB Inverse association with ER-α66 expression
BC Shi, et al.[38] 896 BC tissues IHC ER-α66+/ER-α36Hi tumors are less likely to benefit from tamoxifen treatment than ER-α66+/ER-α36- tumors
BC Zheng, et al.[59] 74 pairs of BC tissues and matched normal tissues PCR Lower expression in BC tissues than in matched normal tissues.
Inverse association with local progression/lymph node metastasis/advanced cancer stage.
BC Zhang, et al.[34] 12 triple-negative BC tissues IHC Expressed in triple-negative BC
BC Pelekanou, et al.[58] 49 triple-negative BC tissues % 34 matched normal samples IHC Highly expressed in triple negative BC.
Positive association with overall survival rate
BC Vranic, et al.[33] 19 pure apocrine carcinomas and 11 adenoid cystic carcinomas of the breast IHC Highly expressed in ER-α66 negative apocrine and adenoid cystic carcinomas of the breast.
Higher expression in the malignant epithelium than adjacent normal breast tissue
BC Zhang, et al.[35] 20 BC tissues IHC Inverse association with ER-α66 expression
EC Tu, et al.[17] 45 EC tissues IHC Positive association with high-stage/high-grade
EC Sun, et al. [60] 73 EC tissues, 20 normal endometrial tissues % 9 atypical endometrial hyperplasia IHC Lower expression in EC tissues than in normal endometrial tissues and atypical hyperplasia.
Inverse association with disease-free survival rate
HCC Miceli, et al.[20] 5 normal liver tissues,8 liver cirrhosis specimens % 8 HCC tissues PCR Inverse association with ER-α66 expression.
Increase in a stepwise manner from non-tumoural tissues, cirrhotic tissues to HCC tissues.
CRC Jiang, et al.[18] 35 CRC tissues and their matched normal tissues PCR Lower expression in CRC than matched normal tissues.
Inverse association with tumour stage/lymph node metastasis.
GC Deng, et al.[61] 22 GC tissues IHC Higher expression in GC than paired normal tissues.
Positive association with lymph node metastasis
GC Wang, et al.[19] 45 GC tissues and matched normal tissues PCR Lower expression in GC than normal tissues
  1. (*) Tumor type: BC: Breast Cancer, EC: Endometrial Cancer, HCC: Hepatocellular Carcinoma, CRC: Colorectal Cancer, GC: Gastric Cancer.
  2. (**) Method: WB: Western blotting, IHC: Immunohistochemistry, PCR: Polymerase chain reaction.