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Table 1 Expression of ER-α36 in cancers

From: The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors

Tumor type (*)

Study

Kind/num. of analyzed samples

Method (**)

Potential clinical significant

BC

Lee, et al.[16]

37 BC tissues

IHC/WB

Inverse association with ER-α66 expression

BC

Shi, et al.[38]

896 BC tissues

IHC

ER-α66+/ER-α36Hi tumors are less likely to benefit from tamoxifen treatment than ER-α66+/ER-α36- tumors

BC

Zheng, et al.[59]

74 pairs of BC tissues and matched normal tissues

PCR

Lower expression in BC tissues than in matched normal tissues.

Inverse association with local progression/lymph node metastasis/advanced cancer stage.

BC

Zhang, et al.[34]

12 triple-negative BC tissues

IHC

Expressed in triple-negative BC

BC

Pelekanou, et al.[58]

49 triple-negative BC tissues % 34 matched normal samples

IHC

Highly expressed in triple negative BC.

Positive association with overall survival rate

BC

Vranic, et al.[33]

19 pure apocrine carcinomas and 11 adenoid cystic carcinomas of the breast

IHC

Highly expressed in ER-α66 negative apocrine and adenoid cystic carcinomas of the breast.

Higher expression in the malignant epithelium than adjacent normal breast tissue

BC

Zhang, et al.[35]

20 BC tissues

IHC

Inverse association with ER-α66 expression

EC

Tu, et al.[17]

45 EC tissues

IHC

Positive association with high-stage/high-grade

EC

Sun, et al. [60]

73 EC tissues, 20 normal endometrial tissues % 9 atypical endometrial hyperplasia

IHC

Lower expression in EC tissues than in normal endometrial tissues and atypical hyperplasia.

Inverse association with disease-free survival rate

HCC

Miceli, et al.[20]

5 normal liver tissues,8 liver cirrhosis specimens % 8 HCC tissues

PCR

Inverse association with ER-α66 expression.

Increase in a stepwise manner from non-tumoural tissues, cirrhotic tissues to HCC tissues.

CRC

Jiang, et al.[18]

35 CRC tissues and their matched normal tissues

PCR

Lower expression in CRC than matched normal tissues.

Inverse association with tumour stage/lymph node metastasis.

GC

Deng, et al.[61]

22 GC tissues

IHC

Higher expression in GC than paired normal tissues.

Positive association with lymph node metastasis

GC

Wang, et al.[19]

45 GC tissues and matched normal tissues

PCR

Lower expression in GC than normal tissues

  1. (*) Tumor type: BC: Breast Cancer, EC: Endometrial Cancer, HCC: Hepatocellular Carcinoma, CRC: Colorectal Cancer, GC: Gastric Cancer.
  2. (**) Method: WB: Western blotting, IHC: Immunohistochemistry, PCR: Polymerase chain reaction.