From: The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors
Tumor type (*) | Study | Kind/num. of analyzed samples | Method (**) | Potential clinical significant |
---|---|---|---|---|
BC | Lee, et al.[16] | 37 BC tissues | IHC/WB | Inverse association with ER-α66 expression |
BC | Shi, et al.[38] | 896 BC tissues | IHC | ER-α66+/ER-α36Hi tumors are less likely to benefit from tamoxifen treatment than ER-α66+/ER-α36- tumors |
BC | Zheng, et al.[59] | 74 pairs of BC tissues and matched normal tissues | PCR | Lower expression in BC tissues than in matched normal tissues. |
Inverse association with local progression/lymph node metastasis/advanced cancer stage. | ||||
BC | Zhang, et al.[34] | 12 triple-negative BC tissues | IHC | Expressed in triple-negative BC |
BC | Pelekanou, et al.[58] | 49 triple-negative BC tissues % 34 matched normal samples | IHC | Highly expressed in triple negative BC. |
Positive association with overall survival rate | ||||
BC | Vranic, et al.[33] | 19 pure apocrine carcinomas and 11 adenoid cystic carcinomas of the breast | IHC | Highly expressed in ER-α66 negative apocrine and adenoid cystic carcinomas of the breast. |
Higher expression in the malignant epithelium than adjacent normal breast tissue | ||||
BC | Zhang, et al.[35] | 20 BC tissues | IHC | Inverse association with ER-α66 expression |
EC | Tu, et al.[17] | 45 EC tissues | IHC | Positive association with high-stage/high-grade |
EC | Sun, et al. [60] | 73 EC tissues, 20 normal endometrial tissues % 9 atypical endometrial hyperplasia | IHC | Lower expression in EC tissues than in normal endometrial tissues and atypical hyperplasia. |
Inverse association with disease-free survival rate | ||||
HCC | Miceli, et al.[20] | 5 normal liver tissues,8 liver cirrhosis specimens % 8 HCC tissues | PCR | Inverse association with ER-α66 expression. |
Increase in a stepwise manner from non-tumoural tissues, cirrhotic tissues to HCC tissues. | ||||
CRC | Jiang, et al.[18] | 35 CRC tissues and their matched normal tissues | PCR | Lower expression in CRC than matched normal tissues. |
Inverse association with tumour stage/lymph node metastasis. | ||||
GC | Deng, et al.[61] | 22 GC tissues | IHC | Higher expression in GC than paired normal tissues. |
Positive association with lymph node metastasis | ||||
GC | Wang, et al.[19] | 45 GC tissues and matched normal tissues | PCR | Lower expression in GC than normal tissues |