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Figure 4 | Journal of Translational Medicine

Figure 4

From: The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors

Figure 4

Interactions between ER-α36 and EGFR in mitogenic signaling. After treatment with estrogen, ER-α36 is dissociated from epidermal growth factor receptor (EGFR) and is associated with Src and Shc. Furthermore, E2 induces auto-phosphorylation of Src and Src-dependent phosphorylation of EGFR. EGFR activates signal transducer and activator of transcription 5(STAT5), which leads to transcription of target genes such as Cyclin D1. On the other hand, ER-α36 and EGFR complex mediated non-genomic signaling like MAPK/ERK pathway is also involved in the signaling pathway contributing to cell proliferation.

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