Table 2 Results of the over-representation analysis of the predicted target genes
From: An eight-miRNA signature as a potential biomarker for predicting survival in lung adenocarcinoma
Subcategory name | P-value (FDR) | Expected | Observed | Involved experimentally validated target genes of the prognostic miRNA | |
|---|---|---|---|---|---|
NSCLC | 0.00336054 | 21.2903 | 34 | miR-31 | CCND1 CDKN2A E2F2 E2F3 KRAS P53 |
miR-196b | CCND1 | ||||
miR-187 | KRAS | ||||
miR-519a-1 | CCND1 | ||||
miR-375 | AKT2 CDK6 PDPK1 | ||||
miR-101-1 | CDKN2A PRKCA | ||||
SCLC | 0.00918204 | 33.1182 | 47 | miR-31 | CCND1 CDKN2B TP53 |
miR-196b | BCL2 CCND1 | ||||
miR-519a-1 | BCL2 | ||||
miR-375 | AKT2 CDK6 | ||||
miR-101-1 | ITGA2 ITGA3 ITGAV | ||||
Apoptosis | 0.00558373 | 34.6953 | 50 | miR-31 | MYD88 TNF TP53 |
miR-196b | BCL2 | ||||
miR-519a-1 | ATM BCL2 | ||||
miR-375 | AKT2 | ||||
miR-101-1 | ATM | ||||
p53 signaling pathway | 0.0149892 | 27.2043 | 39 | miR-31 | CCND1 TP53 |
miR-196b | CCND1 | ||||
miR-519a-1 | CCND1 GADD45A | ||||
miR-375 | CDK6 | ||||
miR-101-1 | ATM CDKN2A | ||||
Ras protein signal transduction | 2.20423e-07 | 87.7829 | 131 | miR-31 | CDKN2A FGF2 KRAS TIAM1 TP53 |
miR-187 | KRAS | ||||
miR-375 | MAPK3 MAPK14 | ||||
| Â | Â | Â | Â | miR-101-1 | BCR CDKN2A CSF1 |