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Table 1 Joint inflammation and cartilage damage on day 3, 7 and 14 of antigen-induced arthritis as assessed by histological scoring

From: Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis

Species

Days

Hyperplasia

Synovial infiltrate

Exudate

Cartilage depletion

Arthritis index

Control animals

3

1.75 ± 0.29

3.56 ± 0.40

2.78 ± 0.15

1.78 ± 0.33

9.89 ± 0.88

7

2.43 ± 0.23

3.93 ± 0.39

2.14 ± 0.46

1.71 ± 0.52

10.2 ± 1.46

 

14

1.67 ± 0.67

1.67 ± 1.20

1.17 ± 0.92

1.50 ± 0.87

6.00 ± 3.61

MSC treated animals

3

1.70 ± 0.17

2.83 ± 0.25

1.13 ± 0.32***

0.33 ± 0.14***

5.96 ± 0.57***

7

1.19 ± 0.28*

2.69 ± 0.43

0.75 ± 0.31*

0.44 ± 0.29*

5.06 ± 1.09*

 

14

1.00 ± 0.00 (p = 0.39)

1.00 ± 0.41 (p = 0.58)

0.00 ± 0.00 (p = 0.19)

0.00 ± 0.00 (p = 0.09)

2.00 ± 0.41 (p = 0.25)

  1. Synovial hyperplasia of the lining layer, synovial infiltration of the sublining by leukocytes, exudate in the joint cavity, and loss of proteoglycan from the articular cartilage were observed in haematoxylin/eosin and toluidine blue stained sections. Sections were scored blind by two independent observers from 0 to 3 (hyperplasia, exudate and cartilage depletion) or 0 to 5 (infiltrate). The arthritis index is the sum of all observations. *p < 0.05; and ***p < 0.001 of the parameter compared to control animals at the same point, using unpaired t test. n = 6 mice.