Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Table 1 Clinicopathological data with univariate and multivariable analysis for disease specific survival within the CRC cohort

Clinicopathological parameters	Patient number (n)	Univariate				Multivariable
		HR	95% CI		P value	HR	95% CI		P value
			Lower	Upper			Lower	Upper
Dukes		3.34	1.61	7.01	0.001	0.33	0.08	1.36	0.12
A	13
B	29
C	8
Gender		1.77	0.73	4.31	0.26	N/A
M	24
F	26
Age at diagnosis		0.99	0.92	1.05	0.773	N/A
30s	5
40s	27
50s	18
T stage		3.04	1.53	6.03	0.001	5.22	1.77	15.44	0.03
pT1	7
PT2	7
pT3	27
pT4	9
N Stage		2.62	1.54	4.46	<0.001	1.62	0.69	3.81	0.27
N0	40
N1	8
N2	1
N3	1
Differentiation		1.14	0.37	3.54	0.83	N/A
Well	5
Moderate	39
Poor	6
Histology		0.49	0.11	2.11	0.34	N/A
Standard	42
Mucinous	8
Site		0.77	0.45	1.31	0.33	N/A
Rectal	17
Right side	17
Left side	16
Budding		5.76	2.38	13.8	0.0005	2.56	0.9	7.27	0.08
High	13
Medium	19
Low	18
LVI		9.99	3.57	27.98	0.0001	6.08	1.17	31.41	0.03
High	13
Medium	19
Low	18
LVD		5.15	2.04	12.99	0.00001	1.3	0.3	5.59	0.72
High	18
Medium	11
Low	21

N/A indicates that the parameter was not included for multivariable analysis due to insignificance in univariate analysis. A parameter with a hazard ratio (HR) of greater than one has an adverse effect on survival and a p value of less than 0.05 was considered significant (bold type).

ISSN: 1479-5876