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Table 1 Clinicopathological data with univariate and multivariable analysis for disease specific survival within the CRC cohort

From: Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Clinicopathological parameters Patient number (n) Univariate Multivariable
HR 95% CI P value HR 95% CI P value
  Lower Upper    Lower Upper  
Dukes   3.34 1.61 7.01 0.001 0.33 0.08 1.36 0.12
A 13         
B 29         
C 8         
Gender   1.77 0.73 4.31 0.26 N/A    
M 24         
F 26         
Age at diagnosis   0.99 0.92 1.05 0.773 N/A    
30s 5         
40s 27         
50s 18         
T stage   3.04 1.53 6.03 0.001 5.22 1.77 15.44 0.03
pT1 7         
PT2 7         
pT3 27         
pT4 9         
N Stage   2.62 1.54 4.46 <0.001 1.62 0.69 3.81 0.27
N0 40         
N1 8         
N2 1         
N3 1         
Differentiation   1.14 0.37 3.54 0.83 N/A    
Well 5         
Moderate 39         
Poor 6         
Histology   0.49 0.11 2.11 0.34 N/A    
Standard 42         
Mucinous 8         
Site   0.77 0.45 1.31 0.33 N/A    
Rectal 17         
Right side 17         
Left side 16         
Budding   5.76 2.38 13.8 0.0005 2.56 0.9 7.27 0.08
High 13         
Medium 19         
Low 18         
LVI   9.99 3.57 27.98 0.0001 6.08 1.17 31.41 0.03
High 13         
Medium 19         
Low 18         
LVD   5.15 2.04 12.99 0.00001 1.3 0.3 5.59 0.72
High 18         
Medium 11         
Low 21         
  1. N/A indicates that the parameter was not included for multivariable analysis due to insignificance in univariate analysis. A parameter with a hazard ratio (HR) of greater than one has an adverse effect on survival and a p value of less than 0.05 was considered significant (bold type).