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Table 1 The predicted top ten combinations of drugs for the treatment of type 2 diabetes

From: Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes

Drug 1 Drug 2 m1 n1 m2 n2 Score
Trifluridine Trolox C 22 8 61 24 518
Thiethylperazine Trolox C 17 6 63 17 506
Cytisine Trolox C 15 6 60 8 468
Cytisine Ozagrel 23 8 48 20 420
Prenylamine Thiethylperazine 17 1 42 16 416
Paclitaxel Trolox C 12 4 61 10 408
Vinburnine Trolox C 18 4 53 24 406
Ozagrel Paclitaxel 22 7 47 20 405
Cytisine Vancomycin 18 7 59 23 396
Valproic acid Trifluridine 20 9 60 24 396
  1. m1-the number of reversed genes by drug 1.
  2. n1-the number of genes induced to the same deregulation as type 2 diabetes by drug 1.
  3. M2-the number of reversed genes by drug 2.
  4. n2-the number of genes induced to the same deregulation as type 2 diabetes by drug 2.