GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy

Table 2 Univariate and multivariate analysis of GOLPH3 in patients who received 5-FU-based chemotherapy with respect to DFS

Variables	Univariate		P	Multivariate		P
	HR	95% CI		HR	95% CI
Age (≥60 yr vs <60 yr)	1.037	0.583−1.844	0.901
Gender (Male vs Female)	2.318	1.179−4.556	0.015	2.011	0.980−4.128	0.057
Tumor location (Rectum vs Colon )	0.958	0.476−1.929	0.904
Tumor size (>4 cm vs ≤4 cm)	1.424	0.751−2.699	0.279
TNM stage (III/IV vs II)	11.545	3.578−37.253	<0.0001	29.406	4.031−214.527	<0.0001
Histological type (Mucinous Vs Adenocarcinoma)	1.086	0.337−3.501	0.89
Tumor differentiation (Poor/moderate vs Well)	2.794	0.865−9.025	0.086
GOLPH3 expression (High vs Low)	0.334	0.159−0.702	0.004	0.468	0.222−0.987	0.046

HR hazard ratio, CI confidence interval, P values in bold were statistically significant.

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