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Table 2 Univariate and multivariate analysis of GOLPH3 in patients who received 5-FU-based chemotherapy with respect to DFS

From: GOLPH3 predicts survival of colorectal cancer patients treated with 5-fluorouracil-based adjuvant chemotherapy

Variables Univariate P Multivariate P
  HR 95% CI   HR 95% CI  
Age (≥60 yr vs <60 yr) 1.037 0.583−1.844 0.901    
Gender (Male vs Female) 2.318 1.179−4.556 0.015 2.011 0.980−4.128 0.057
Tumor location (Rectum vs Colon ) 0.958 0.476−1.929 0.904    
Tumor size (>4 cm vs ≤4 cm) 1.424 0.751−2.699 0.279    
TNM stage (III/IV vs II) 11.545 3.578−37.253 <0.0001 29.406 4.031−214.527 <0.0001
Histological type (Mucinous Vs Adenocarcinoma) 1.086 0.337−3.501 0.89    
Tumor differentiation (Poor/moderate vs Well) 2.794 0.865−9.025 0.086    
GOLPH3 expression (High vs Low) 0.334 0.159−0.702 0.004 0.468 0.222−0.987 0.046
  1. HR hazard ratio, CI confidence interval, P values in bold were statistically significant.