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Table 4 The sensitivity, specificity, and accuracy of weighted enzymatic chip array for KRAS mutation detection

From: Detection of activated KRAS from cancer patient peripheral blood using a weighted enzymatic chip array

 

Direct sequencinga

       
 

Mutation (N = 127)

Wild type (N = 263 )

Total

Sensitivity

Specificity

PPVc

NPVd

Accuracy

P-value

 

(95% CI)

(95% CI)

(95% CI)

(95% CI)

(95% CI)

 

WEnCAb

         

Positive

117

14

131

92.13%

94.68%

89.31%

96.14%

93.85%

<0.001

Negative

10

249

259

(86.11-95.67%)

(91.26-96.8%)

(82.86-93.53%)

(93.04-97.89%)

(91.47-96.23%)

 
  1. a KRAS in tumor tissues (direct sequencing).
  2. b KRAS in peripheral blood (weighted enzymatic chip array; WEnCA).
  3. cPPV: positive predictive value.
  4. dNPV: negative predictive value.
  5. 95% CI: 95% confidence interval.