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Table 4 The sensitivity, specificity, and accuracy of weighted enzymatic chip array for KRAS mutation detection

From: Detection of activated KRAS from cancer patient peripheral blood using a weighted enzymatic chip array

  Direct sequencinga        
  Mutation (N = 127) Wild type (N = 263 ) Total Sensitivity Specificity PPVc NPVd Accuracy P-value
  (95% CI) (95% CI) (95% CI) (95% CI) (95% CI)  
WEnCAb          
Positive 117 14 131 92.13% 94.68% 89.31% 96.14% 93.85% <0.001
Negative 10 249 259 (86.11-95.67%) (91.26-96.8%) (82.86-93.53%) (93.04-97.89%) (91.47-96.23%)  
  1. a KRAS in tumor tissues (direct sequencing).
  2. b KRAS in peripheral blood (weighted enzymatic chip array; WEnCA).
  3. cPPV: positive predictive value.
  4. dNPV: negative predictive value.
  5. 95% CI: 95% confidence interval.