Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Table 2 Haemodynamic function in hearts of Control and Iso/Ade groups with or without cyclosporine A

Parameters	Pre-Ischaemia (n = 24)	Reperfusion (Percentage preischaemic value)
Parameters	Pre-Ischaemia (n = 24)	Control (n = 7)		Iso/Ade (n = 6)	CsA (n = 5)	Iso/Ade + CsA (n = 6)
LVDP (mmHg)	75.8 ± 2.9	% of initial values	39.0 ± 6.6	100.5 ± 14.2 *	89.5 ± 14.4	97.8 ± 16.9 *
HR (beat/min)	288.3 ± 3.9		96.0 ± 3.5	93.1 ± 3.1	99.3 ± 4.7	102.9 ± 2.9
RPP (mmHg · beat/min)	21854 ± 889		38.8 ± 7.5	93.0 ± 12.0 **	86.3 ± 13.3 *	100.3 ± 11.2 **
+dP/dt (mmHg/s)	2969 ± 94		34.2 ± 4.6	81.3 ± 12.3 *	66.4 ± 13.3	87.2 ± 14.3 *
-dP/dt (mmHg/s)	−2074 ± 84		42.7 ± 4.7	93.6 ± 12.4 **	71.7 ± 8.3	90.8 ± 13.5 *
Maximal LVEDP at Reperfusion (mmHg)	-	98.6 ± 5.6		53.9 ± 13.2 **	78.2 ± 8.6	65.9 ± 4.2 *

Haemodynamic function was determined at the end of equilibration period prior to ischaemia and after 60 min reperfusion. The perfusion protocol of Iso/Ade group in this series of experiments was similar to that of Iso/Ade-0 group in Experimental Series 1.
* P < 0.05, ** P < 0.01, *** P < 0.001 vs. Control.

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