Skip to main content

Advertisement

Table 2 Haemodynamic function in hearts of Control and Iso/Ade groups with or without cyclosporine A

From: Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Parameters Pre-Ischaemia (n = 24) Reperfusion (Percentage preischaemic value)
Control (n = 7) Iso/Ade (n = 6) CsA (n = 5) Iso/Ade + CsA (n = 6)
LVDP (mmHg) 75.8 ± 2.9 % of initial values 39.0 ± 6.6 100.5 ± 14.2 * 89.5 ± 14.4 97.8 ± 16.9 *
HR (beat/min) 288.3 ± 3.9 96.0 ± 3.5 93.1 ± 3.1 99.3 ± 4.7 102.9 ± 2.9
RPP (mmHg · beat/min) 21854 ± 889 38.8 ± 7.5 93.0 ± 12.0 ** 86.3 ± 13.3 * 100.3 ± 11.2 **
+dP/dt (mmHg/s) 2969 ± 94 34.2 ± 4.6 81.3 ± 12.3 * 66.4 ± 13.3 87.2 ± 14.3 *
-dP/dt (mmHg/s) −2074 ± 84 42.7 ± 4.7 93.6 ± 12.4 ** 71.7 ± 8.3 90.8 ± 13.5 *
Maximal LVEDP at Reperfusion (mmHg) - 98.6 ± 5.6 53.9 ± 13.2 ** 78.2 ± 8.6 65.9 ± 4.2 *
  1. Haemodynamic function was determined at the end of equilibration period prior to ischaemia and after 60 min reperfusion. The perfusion protocol of Iso/Ade group in this series of experiments was similar to that of Iso/Ade-0 group in Experimental Series 1.
  2. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Control.