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Table 1 Haemodynamic function in Iso/Ade groups of hearts with different duration of the washout period

From: Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Parameters

Preiscaemic equilibration (n = 34)

Reperfusion (Percentage preischaemic value)

Control (n = 7)

Iso/Ade-0 (n = 10)

Iso/Ade-5 (n = 9)

Iso/Ade-10 (n = 8)

LVDP (mmHg)

75.1 ± 2.5

% of initial values

29.4 ± 5.7

88.9 ± 7.2 ***

73.6 ± 8.3 *

78.3 ± 14.9 *

HR (beat/min)

277.6 ± 4.2

102.5 ± 11.4

86.9 ± 5.6

94.5 ± 3.2

71.6 ± 8.9

RPP (mmHg · beat/min)

20802 ± 713

28.5 ± 5.2

76.3 ± 6.9 ***

68.5 ± 7.0 **

73.3 ± 10.5 **

+dP/dt (mmHg/s)

3082 ± 117

30.2 ± 2.5

65.2 ± 6.9 **

58.6 ± 5.3 *

60.4 ± 8.5 *

-dP/dt (mmHg/s)

−2027 ± 83

42.7 ± 4.4

85.5 ± 7.2 **

65.6 ± 8.2

71.5 ± 8.9

Maximal LVEDP at Reperfusion (mmHg)

-

98.7 ± 7.5

50.0 ± 4.4 ***

62.1 ± 8.2 **

63.2 ± 6.5 **

  1. Haemodynamic function was determined at the end of the equilibration period prior to ischaemia and after 60 min reperfusion.
  2. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Control.