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Table 1 Haemodynamic function in Iso/Ade groups of hearts with different duration of the washout period

From: Clinically-relevant consecutive treatment with isoproterenol and adenosine protects the failing heart against ischaemia and reperfusion

Parameters Preiscaemic equilibration (n = 34) Reperfusion (Percentage preischaemic value)
Control (n = 7) Iso/Ade-0 (n = 10) Iso/Ade-5 (n = 9) Iso/Ade-10 (n = 8)
LVDP (mmHg) 75.1 ± 2.5 % of initial values 29.4 ± 5.7 88.9 ± 7.2 *** 73.6 ± 8.3 * 78.3 ± 14.9 *
HR (beat/min) 277.6 ± 4.2 102.5 ± 11.4 86.9 ± 5.6 94.5 ± 3.2 71.6 ± 8.9
RPP (mmHg · beat/min) 20802 ± 713 28.5 ± 5.2 76.3 ± 6.9 *** 68.5 ± 7.0 ** 73.3 ± 10.5 **
+dP/dt (mmHg/s) 3082 ± 117 30.2 ± 2.5 65.2 ± 6.9 ** 58.6 ± 5.3 * 60.4 ± 8.5 *
-dP/dt (mmHg/s) −2027 ± 83 42.7 ± 4.4 85.5 ± 7.2 ** 65.6 ± 8.2 71.5 ± 8.9
Maximal LVEDP at Reperfusion (mmHg) - 98.7 ± 7.5 50.0 ± 4.4 *** 62.1 ± 8.2 ** 63.2 ± 6.5 **
  1. Haemodynamic function was determined at the end of the equilibration period prior to ischaemia and after 60 min reperfusion.
  2. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. Control.