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Table 3 Multi-localization EGFR CNV screening

From: Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

 

Number and type of samples analyzed per patients

EGFR CNV results

Patients

Mutation type

Primary tumor(sugical sample,lung biopsy*, bronchial biospy£

Pleural biopsy

Lymph node

Cytology: Pleural effusion,Bronchial Aspiration*

EGFR CNV ≥ 2.5

EGFR CNV < 2.5

Non contributive samples

P1

del19

7

0

0

0

5

2

 

P2

del19

2

0

0

0

 

2

 

P3

del19

0

3

0

1

 

3

1

P4

del19

0

4

0

1

1

3

1

P5

del19

0

3

0

1

1

3

 

P6

del19

1* + 1*

0

0

0

1

1

 

P7

del19

0

0

0

2

1

1

 

P8

del19

1* + 1*

0

0

0

1

1

 

P9

del19

3

1

0

0

1

3

 

P10

del19

0

3

0

0

 

1

2

P11

del19

0

3

0

0

3

  

P12

del19

0

3

0

0

1

2

 

P13

del19

4

0

0

0

 

4

 

P14

del19

2

0

0

0

 

2

 

P15

del19

0

2

0

1

 

3

 

P16

del19

1£ + 1£

0

0

1*

 

1

2

P17

del19

3

0

0

0

1

1

1

P18

del19

0

0

1

1*

 

1

1

P19

del19

1 + 1*

0

0

0

 

1

1

P20

p.G719A

1

0

4

0

1

2

2

P21

p.G719A

5

0

2

0

 

6

1

P22

ins20

3

0

1

0

2

2

 

P23

ins20

0

2

0

0

 

2

 

P24

ins20

3

0

2

0

 

4

1

P25

ins20

0

2

0

0

1

1

 

P26

ins20

3

0

0

0

 

3

 

P27

ins20

2 + 1

0

1 + 1

0

 

4

1

P28

p.L858R

4

0

2

0

 

6

 

P29

p.L858R

1£ + 1£

0

0

0

1

1

 

P30

p.L858R

2

0

0

0

 

2

 

P31

p.L858R

3

0

0

0

 

3

 

P32

p.L858R

0

3

0

1

2

2

 

P33

p.L858R

0

3

0

0

1

1

1

P34

p.L858R

1

0

1

1

 

2

P35

p.L858R

4

0

2

0

 

6

 

P36

p.L858R

2

0

1

0

 

2

1

P37

p.L858R

3

0

0

0

 

2

1

P38

p.L858R

3

0

0

0

1

2

 

P39

p.L858R

3

0

0

0

 

2

1

P40

p.L861Q/ p.T790M

19

0

0

0

 

18

1

  1. Shows the type and number of samples tested for EGFR copy number variation (CNV) in 40 patients. Non-contributive samples are non-amplified specimens or samples with Ct >30.
  2. Lung biopsy: * and bronchial biopsy: £.