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Table 3 Multi-localization EGFR CNV screening

From: Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

  Number and type of samples analyzed per patients EGFR CNV results
Patients Mutation type Primary tumor(sugical sample,lung biopsy*, bronchial biospy£ Pleural biopsy Lymph node Cytology: Pleural effusion,Bronchial Aspiration* EGFR CNV ≥ 2.5 EGFR CNV < 2.5 Non contributive samples
P1 del19 7 0 0 0 5 2  
P2 del19 2 0 0 0   2  
P3 del19 0 3 0 1   3 1
P4 del19 0 4 0 1 1 3 1
P5 del19 0 3 0 1 1 3  
P6 del19 1* + 1* 0 0 0 1 1  
P7 del19 0 0 0 2 1 1  
P8 del19 1* + 1* 0 0 0 1 1  
P9 del19 3 1 0 0 1 3  
P10 del19 0 3 0 0   1 2
P11 del19 0 3 0 0 3   
P12 del19 0 3 0 0 1 2  
P13 del19 4 0 0 0   4  
P14 del19 2 0 0 0   2  
P15 del19 0 2 0 1   3  
P16 del19 1£ + 1£ 0 0 1*   1 2
P17 del19 3 0 0 0 1 1 1
P18 del19 0 0 1 1*   1 1
P19 del19 1 + 1* 0 0 0   1 1
P20 p.G719A 1 0 4 0 1 2 2
P21 p.G719A 5 0 2 0   6 1
P22 ins20 3 0 1 0 2 2  
P23 ins20 0 2 0 0   2  
P24 ins20 3 0 2 0   4 1
P25 ins20 0 2 0 0 1 1  
P26 ins20 3 0 0 0   3  
P27 ins20 2 + 1 0 1 + 1 0   4 1
P28 p.L858R 4 0 2 0   6  
P29 p.L858R 1£ + 1£ 0 0 0 1 1  
P30 p.L858R 2 0 0 0   2  
P31 p.L858R 3 0 0 0   3  
P32 p.L858R 0 3 0 1 2 2  
P33 p.L858R 0 3 0 0 1 1 1
P34 p.L858R 1 0 1 1   2
P35 p.L858R 4 0 2 0   6  
P36 p.L858R 2 0 1 0   2 1
P37 p.L858R 3 0 0 0   2 1
P38 p.L858R 3 0 0 0 1 2  
P39 p.L858R 3 0 0 0   2 1
P40 p.L861Q/ p.T790M 19 0 0 0   18 1
  1. Shows the type and number of samples tested for EGFR copy number variation (CNV) in 40 patients. Non-contributive samples are non-amplified specimens or samples with Ct >30.
  2. Lung biopsy: * and bronchial biopsy: £.