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Table 2 Multi-localization EGFR genotyping screening

From: Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?

  Number and type of samples analyzed per patients EGFR genotyping results
Patients Mutation type Primary tumor(sugical sample,lung biopsy*,bronchial biospy£) PLEURAL BIOPSY LYMPH NODE Cytology: Pleural Effusion,Bronchial aspiration* Contributive samples Concordant EGFR status Non contributive samples Discordant EGFR status
P1 del19 7 0 0 0 7 7 0  
P2 del19 2 0 0 0 2 2 0  
P3 del19 0 3 0 1 4 3 0 1 (rescued by CAST PCR)
P4 del19 0 4 0 1 5 5 0  
P5 del19 0 3 0 1 4 4 0  
P6 del19 1* + 1* 0 0 0 2 2 0  
P7 del19 0 0 0 2 2 2 0  
P8 del19 1* + 1* 0 0 0 2 2 0  
P9 del19 3 1 0 0 4 4 0  
P10 del19 0 3 0 0 3 3 0  
P11 del19 0 3 0 0 3 3 0  
P12 del19 0 3 0 0 2 2 1  
P13 del19 4 0 0 0 4 4 0  
P14 del19 2 0 0 0 2 2 0  
P15 del19 0 2 0 1 3 3 0  
P16 del19 1£ +  0 0 1* 3 1 0 2 (remained WT by CAST PCR)
P17 del19 3 0 0 0 3 3 0  
P18 del19 0 0 1 1* 1 1 1  
P19 del19 1 + 1* 0 0 0 2 2 0  
P20 p.G719A 1 0 4 0 5 5 0  
P21 p.G719A 5 0 2 0 7 7 0  
P22 ins20 3 0 1 0 4 4 0  
P23 ins20 0 2 0 0 2 2 0  
P24 ins20 3 0 2 0 4 4 1  
P25 ins20 0 2 0 0 2 2 0  
P26 ins20 3 0 0 0 3 3 0  
P27 ins20 2 + 1 0 1 + 1 0 4 2 1 2
P28 p.L858R 4 0 2 0 6 6 0  
P29 p.L858R 1£ + 1£ 0 0 0 2 2 0  
P30 p.L858R 2 0 0 0 2 2 0  
P31 p.L858R 3 0 0 0 3 3 0  
P32 p.L858R 0 3 0 1 4 4 0  
P33 p.L858R 0 3 0 0 3 3 0  
P34 p.L858R 1 0 1 3 3 0  
P35 p.L858R 4 0 2 0 6 6 0  
P36 p.L858R 2 0 1 0 3 3 0  
P37 p.L858R 3 0 0 0 3 3 0  
P38 p.L858R 3 0 0 0 3 3 0  
P39 p.L858R 3 0 0 0 3 3 0  
P40 p.L861Q/p.T790M 19 0 0 0 19 19 0  
  1. Shows the type and number of samples tested for EGFR mutation in 40 patients. Non-contributive samples are non-amplified specimens. Discordant samples are DNAs that have been found wild type when a mutation was expected. The discordant samples are italic. Lung biopsy: *and bronchial biopsy: £.