Figure 1
NIH clinical collection compounds/drugs screened in vitro with U87 human GBM cells. (A) All 446 compounds in the NCC drug panel ordered according to percent viability after treatment, note the shoulder at the end indicating 22 agents with anti-GBM activity. (B) The 22 positive compounds retested with three replicates. (C) IC50 of the most active and available compounds screened with four widely used, established GBM cell lines. The predicted BBB value for each compound is shown.