Figure 5
From: In silico modeling predicts drug sensitivity of patient-derived cancer cells
In silico modeling and experimental in vitro data for drug responsiveness to tyrosine kinase inhibitors. This figure demonstrates in silico predictions of sensitivity and in vitro viability (respectively) in response to treatment with tyrosine kinase inhibitors: A, B, lapatinib, C, D, nilotinib, E, F, Imatinib and G, H, Sunitinib. Cells were exposed in vitro to 1 μM tyrosine kinase inhibitors for 72 h and viability determined using Alamar Blue assay. The dose-response for in silico predictions is generated by iterative simulations with increasing concentrations of the drug in the model and the viability index is calculated. Cells showing decrease in viability of 20% or greater are considered sensitive to the drug.