Figure 4
From: In silico modeling predicts drug sensitivity of patient-derived cancer cells
In silico modeling analysis and experimental in vitro data for drug responsiveness to 3 alignment drugs. A, Predictive dose response data for erlotinib with percent change in viability. Cells showing decrease in viability of 20% or greater are considered sensitive to the drug. B, In vitro experimental results for effect of 1 μM erlotinib on viability in patient-derived GBM cell lines; viability was determined at 72 h using Alamar Blue assay. C, D, Predictive and experimental data for sorafenib. E, F, Predictive and experimental data for dasatinib. All drugs were tested in vitro at 1 μM. Dose-response curves for in silico data demonstrate the effects of increasing concentrations of the drugs – erlotinib, sorafenib and sunitinib on the viability of profiled patient-derived GBM cell lines in the simulation model.