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Table 2 Involvement of regulatory T cell (Treg)s in different allergic diseases

From: Subsets of regulatory T cells and their roles in allergy

Disease Location Involvement of Tregs
Allergic dermatitis Skin, the secondary lymphoid organs The depletion of Tregs leads to significantly exacerbated skin inflammation, as well as elevated serum IgE levels [50].
Allergic rhinitis Tonsil, Blood Potential first-line organs of oral tolerance against allergens [49]; allergic rhinitis patients with a good therapeutic outcome after 1 year of SIT, the induced Treg and Th1 responses persist over 3 years of SIT [52].
Allergic airway inflammation Blood, peribronchial lymph nodes Foxp3 expression is reduced and CD25(hi) Treg-suppressive function is deficient in asthma. Corticosteroids and allergen immunotherapy act on Tregs, in part to increase IL-10 production, while vitamin D3 and long-acting beta-agonists enhance Tr1 cell function [57]. Heligmosomoides polygyrus infection is associated with elevated numbers of Tregs in airway challenged mice [60], efficiently protects mice from asthma by induction of accumulation of highly suppressive Tregs in the lungs [61].
  1. SIT = specific immunotherapy.