Table 2 Involvement of regulatory T cell (Treg)s in different allergic diseases
From: Subsets of regulatory T cells and their roles in allergy
Disease | Location | Involvement of Tregs |
|---|---|---|
Allergic dermatitis | Skin, the secondary lymphoid organs | The depletion of Tregs leads to significantly exacerbated skin inflammation, as well as elevated serum IgE levels [50]. |
Allergic rhinitis | Tonsil, Blood | Potential first-line organs of oral tolerance against allergens [49]; allergic rhinitis patients with a good therapeutic outcome after 1Â year of SIT, the induced Treg and Th1 responses persist over 3Â years of SIT [52]. |
Allergic airway inflammation | Blood, peribronchial lymph nodes | Foxp3 expression is reduced and CD25(hi) Treg-suppressive function is deficient in asthma. Corticosteroids and allergen immunotherapy act on Tregs, in part to increase IL-10 production, while vitamin D3 and long-acting beta-agonists enhance Tr1 cell function [57]. Heligmosomoides polygyrus infection is associated with elevated numbers of Tregs in airway challenged mice [60], efficiently protects mice from asthma by induction of accumulation of highly suppressive Tregs in the lungs [61]. |