Figure 6

In vivo ballistic marker in pig liver followed by HIFU sonication. Temperature elevation (°C) (a-c) and lethal thermal dose (>240CEM43) maps (d-f) obtained at the end of HIFU sonication in pig liver. g) - i) T1w VIBE images of the final lesion (HIFU and RF ablation) in pig liver, at Day 7 after Gd administration. j) Post-mortem macroscopic illustration of the ballistic marker and HIFU ablation after 3 weeks of formalin fixation. The difference between the 2 lesions is visible due to the blue coloration of the ballistic marker. FOV = 20 × 20 mm. k) 3D reconstruction of the liver lobe containing the HIFU lesion and the ballistic marker illustrated in frame j: entire HIFU lesion (elongated shape, in red) and the RF marker (in blue) at the periphery; l) microscopic histology, same slice as shown in frame j).