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Table 5 Consistency between BRAF / cKIT / CyclinD1 alterations in paired samples from patients with multiple melanoma

From: Discrepant alterations in main candidate genes among multiple primary melanomas

Tissue type

No. of cases

Cases with consistent mutation patterns, n (%)

BRAF + cKIT + CyclinD1 alterations

BRAF mutations

Subsequent vs. first primary melanoma

Second melanoma

107

53 (49.5)

73 (68.2)

Third/Fourth melanoma

15

7 (46.7)

9 (60.0)

Subsequent vs. second primary melanoma

Third/Fourth melanoma

15

8 (53.3)

11 (73.3)

Multiple melanomas at the same anatomical site (head/neck - trunk - limbs)

All cases

48

25 (52.1)

31 (64.6)

Synchronous

13

7 (53.8)

8 (61.5)

Asynchronous

35

18 (51.4)

23 (65.7)