From: Discrepant alterations in main candidate genes among multiple primary melanomas
Tissue type | No. of cases | Cases with consistent mutation patterns, n (%) | |
---|---|---|---|
BRAF + cKIT + CyclinD1 alterations | BRAF mutations | ||
Subsequent vs. first primary melanoma | |||
Second melanoma | 107 | 53 (49.5) | 73 (68.2) |
Third/Fourth melanoma | 15 | 7 (46.7) | 9 (60.0) |
Subsequent vs. second primary melanoma | |||
Third/Fourth melanoma | 15 | 8 (53.3) | 11 (73.3) |
Multiple melanomas at the same anatomical site (head/neck - trunk - limbs) | |||
All cases | 48 | 25 (52.1) | 31 (64.6) |
Synchronous | 13 | 7 (53.8) | 8 (61.5) |
Asynchronous | 35 | 18 (51.4) | 23 (65.7) |