FOLFOX (n = 89), FOLFOX + Bev (n = 4), XELOX + Bev (n = 1) | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HLA-A*2402-matched (n = 50) | HLA-A*2402-unmatched (n = 46) | |||||||||||||||||||
FOLFOX (n = 48), XELOX (n = 2) | FOLFOX (n = 41) + Bev (n = 4), XELOX + Bev (n = 1) | |||||||||||||||||||
Adverse Event | 1 | 2 | 3 | 4 | 5 | 1 | 2 | 3 | 4 | 5 | ||||||||||
No | % | No | % | No | % | No | % | No | % | No | % | No | % | No | % | No | % | No | % | |
Hand-foot syndrome | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
Allergy | 4 | 8 | 3 | 6 | 2 | 4 | 0 | 0 | 0 | 0 | 3 | 7 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 |
Mucositis | 2 | 4 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nausea/vomiting | 5 | 10 | 1 | 2 | 2 | 4 | 0 | 0 | 0 | 0 | 6 | 13 | 2 | 4 | 1 | 2 | 0 | 0 | 0 | 0 |
Neurologic toxicity | 15 | 30 | 10 | 20 | 4 | 8 | 0 | 0 | 0 | 17 | 37 | 10 | 22 | 5 | 11 | 1 | 2 | 0 | 0 | |
Anorexia | 10 | 20 | 3 | 6 | 4 | 8 | 0 | 0 | 0 | 0 | 10 | 22 | 4 | 9 | 2 | 4 | 0 | 0 | 0 | 0 |
Diarrhea | 3 | 6 | 6 | 12 | 2 | 4 | 0 | 0 | 0 | 0 | 3 | 7 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
Fatigue/Asthenia | 5 | 10 | 1 | 2 | 2 | 4 | 0 | 0 | 0 | 0 | 5 | 11 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 |
Fever | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 7 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Injection site reaction | 18 | 36 | 18 | 36 | 9 | 18 | 0 | 0 | 0 | 0 | 20 | 43 | 17 | 37 | 3 | 13 | 0 | 0 | 0 | 0 |
Interstitial pneumonia | 0 | 0 | 0 | 0 | 4 | 8 | 0 | 0 | 2 | 4 | 0 | 0 | 0 | 0 | 4 | 9 | 0 | 0 | 1 | 2 |
Neutropenia | 5 | 10 | 10 | 20 | 10 | 20 | 1 | 2 | 0 | 0 | 8 | 17 | 14 | 30 | 2 | 4 | 1 | 2 | 0 | 0 |
Leukopenia | 10 | 20 | 12 | 24 | 1 | 2 | 0 | 0 | 0 | 0 | 12 | 26 | 9 | 20 | 2 | 4 | 0 | 0 | 0 | 0 |
Thrombocytopenia | 17 | 34 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 20 | 43 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Bilirubin | 2 | 4 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
AL-P | 11 | 22 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 10 | 22 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Creatinine | 3 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hemoglobin | 11 | 22 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 13 | 28 | 7 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
Embolism | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 |
AST/ALT | 12 | 24 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 6 | 13 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |