Marker panel*
|
Cut-off point†
|
Sensitivity‡
|
Specificity
|
---|
sCD40L
|
0.45
|
80.0%
|
85.5%
|
CA19-9
|
0.35
|
80.0%
|
72.7%
|
CEA
|
0.45
|
68.9%
|
60.0%
|
sCD40L + CA19-9
|
0.35
|
80.0%
|
89.1%
|
sCD40L + CEA
|
0.60
|
80.0%
|
85.5%
|
CA19-9 + CEA
|
0.41
|
80.0%
|
70.9%
|
sCD40L + CA19-9 + CEA
|
0.45
|
84.4%
|
90.9%
|
- sCD40L, soluble CD40 ligand; CA19-9, carbohydrate antigen 19–9; CEA, carcinoembryonic antigen; PDAC, pancreatic ductal adenocarcinoma.
- *Each marker is included as a linear term and evaluated as a panel from one to three markers combination.
-
†Cut-off point refers to the probability cut-off point to classify subjects as having PDAC or non-PDAC in binary logistic regression.
-
‡For comparison among panels, the cut-off point ensures a target sensitivity of around 80%.