Clinical significance of elevated serum soluble CD40 ligand levels as a diagnostic and prognostic tumor marker for pancreatic ductal adenocarcinoma

Table 2 Diagnostic accuracy of combinations of serum sCD40L, CA19-9, and/or CEA to detect PDAC by logistic regression in the validation dataset

Marker panel*	Cut-off point^†	Sensitivity^‡	Specificity
sCD40L	0.45	80.0%	85.5%
CA19-9	0.35	80.0%	72.7%
CEA	0.45	68.9%	60.0%
sCD40L + CA19-9	0.35	80.0%	89.1%
sCD40L + CEA	0.60	80.0%	85.5%
CA19-9 + CEA	0.41	80.0%	70.9%
sCD40L + CA19-9 + CEA	0.45	84.4%	90.9%

sCD40L, soluble CD40 ligand; CA19-9, carbohydrate antigen 19–9; CEA, carcinoembryonic antigen; PDAC, pancreatic ductal adenocarcinoma.
*Each marker is included as a linear term and evaluated as a panel from one to three markers combination.
^†Cut-off point refers to the probability cut-off point to classify subjects as having PDAC or non-PDAC in binary logistic regression.
^‡For comparison among panels, the cut-off point ensures a target sensitivity of around 80%.

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