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Table 2 Comparison of laboratory findings, circulating galectin-3 level and Lp-PLA2 gene expression between day 0 and day 90 after combined clopidogrel and cilostazol treatment among 55 study patients

From: Levels and values of lipoprotein-associated phospholipase A2, galectin-3, RhoA/ROCK, and endothelial progenitor cells in critical limb ischemia: pharmaco-therapeutic role of cilostazol and clopidogrel combination therapy

Variable

Day 0

Day 90

p-value

Red blood cell count (×106)

4.0 ± 0.8

3.8 ± 0.7

0.682

White blood cell count (×103)

8.2 ± 3.2

8.0 ± 2.2

0.574

Platelet count (×103)

250 ± 78

236 ± 115

0.483

Hemoglobin

11.5 ± 2.1

11.1 ± 2.1

0.811

Total cholesterol level

181 ± 52

152 ± 22

< 0.001

Low-density lipoprotein

106 ± 43

79 ± 24

< 0.001

High-density lipoprotein

55 ± 14

58 ± 14

0.001

Creatinine level (mg/dL)

3.23 ± 3.31

3.35 ± 3.46

0.731

Ac sugar

158 ± 76

148 ± 41

0.103

HbA1c

7.28 ± 1.65

6.80 ± 0.92

0.001

Lp-PLA2

1.46 ± 0.10

1.37 ± 0.09

< 0.001

Galectin-3 (ng/ml)

23.09 ± 4.17

15.53 ± 4.33

< 0.001

CD31+/CD34+ (%)

0.77 ± 0.48

0.80 ± 0.56

0.001

KDR+/CD34+ (%)

0.84 ± 0.55

0.89 ± 0.39

< 0.001

CXCR4+/CD34+ (%)

1.10 ± 0.70

1.11 ± 0.89

0.002

  1. Data are expressed as mean ± SD.
  2. Lp-PLA2 = lipoprotein-associated phospholipase A2.