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Table 1 Patient clinical characteristics

From: Multiple therapeutic peptide vaccines consisting of combined novel cancer testis antigens and anti-angiogenic peptides for patients with non-small cell lung cancer

Patients

Age/Gender (M/F)

Stage

Histology*

Lesion§

Performance status (ECOG)

Peptides†

Dose (mg)

Phase of treatment (Prior therapy**)

1

54/M

Recurrence

AD

LN, bone

2

L, T, R1, R2

0.5

5th (PLT, RT)

2

48/M

IIIB

AD

PM, effusion

2

L, T, R1, R2

0.5

5th (PLT)

3

65/M

Recurrence

AD

PM

2

L, T, R1, R2

0.5

6th (PLT, EGFR-TKI)

4

58/M

IV

AD

Primary, bone

2

L, T, R1, R2

1

4th (PLT)

5

60/M

IV

AD

Primary, LN

1

L, T, R1, R2

1

3rd (PLT)

6

47/M

IV

AD

Primary, LN, ADR

0

L, T, R1, R2

1

3rd(PLT, RT)

7

40/M

IIIA

AD

Primary, LN

1

L, T, R1, R2

3

3rd(PLT)

8

69/M

Recurrence

SQ

PM

1

L, T, R1, R2

3

3rd(PLT, RT)

9

65/M

Recurrence

AD

Dissemination

0

L, T, R1, R2

3

2nd(PLT, RT)

10

57/M

Recurrence

PLEO

LN

1

L, C, R1, R2

1

3rd(PLT, RT)

11

55/F

IIIB

AD

Primary, LN, effusion

2

L, C, R1, R2

1

5th(PLT, EGFR-TKI)

12

62/M

Recurrence

AD

PM

1

L, C, R1, R2

1

2nd(PLT)

13

68/F

IV

AD

Primary, bone, effusion

2

L, C, R1, R2

3

2nd(PLT)

14

39/F

IV

NSCLC

Primary, liver, bone

2

L, C, R1, R2

3

2nd(PLT, RT)

15

61/M

Recurrence

AD

PM, LN

1

L, C, R1, R2

3

5th(PLT, RT, EGFR-TKI)

  1. *AD: adenocarcinoma; SQ: squamous cell carcinoma; PLEO: pleomorphic carcinoma; NSCLC: non-small cell lung cancer in which further histological determination was not possible.
  2. §LN: lymph nodes metastasis; bone: bone metastasis; PM: pulmonary metastasis; effusion: malignant pleural effusion; Primary: primary tumor; ADR: adrenal gland metastasis; Dissemination: pleural dissemination; liver: liver metastasis.
  3. † L: LY6K; T: TTK; R1: VEGFR1; R2: VEGFR2; C: CDCA1.
  4. **PLT: platinum containing chemotherapy; RT: radiotherapy; EGFR-TKI: epidermal growth factor receptor tyrosine kinase inhibitor.