Figure 2

Survival analysis of patients. (a) Overall survival curve for the fifteen patients analyzed using the Kaplan-Meier method. The median survival time is 398 days and the 1-year survival rate is 58.3%. (b) Overall survival curve according to the CTL responses (Kaplan-Meier method). Patients with strong positive CTL responses (+++) to two or more peptides (n=7) had a significantly better prognosis than those revealing a strong CTL response to no or only one peptide (n=8, including several patients who had weak CTL responses with + or ++ against multiple peptides. ) (p=0.0176 using the log-rank test). The 1-year survival rates for the group showing a CTL response with multiple peptides and those with no or a single peptide are 85.7% and 33.3%, respectively. As mention above the cutoff levels for CTL were set as (−, +, ++) vs. (+++) in survival analysis.