Intra-osseous injection of donor mesenchymal stem cell (MSC) into the bone marrow in living donor kidney transplantation; a pilot study

Table 3 Modulation of the immune parameters in the MSC-kidney transplantation recipients

No	Age/Sex	Clinical outcome at 12 Month	Tregs¹	Donor-specific lymphocyte proliferation²	Donor-specific T cell proliferation³	Cytokines⁴
1	34/M	Borderline change	↑↑	↑	-	IL-10 at D + 7 IL-6 at D + 7
2	48/F	No AR	↑↑	-	-	IL-10 at D + 30
3	40/M	No AR	-	ND*	ND*	NC**
4	32/F	ACR	-	↑	↑↑	NC**
5	36/M	No AR	-	↓↓	↓↓	IL-6 at D + 7 IFN-γ at D + 30
6	36/F	Borderline change	-	-	-
7	40/F	ACR	-	↓	↓↓	IFN-γ at D + 4

¹Represented by the level of FoxP3mRNA : compared to baseline (D −35) control (Figure 1).
²Peripheral blood lymphocytes were co-cultured with donor cells (MLR) (Figure 2).
³ConA-induced T cell proliferation in the MLR system. (Figure 3).
⁴Cytokines their secretion was significantly increased compared to donor and baseline (D-35) level. (Figures 4, 5, 6).
*ND = Not detected: due to the lack of sample.
**NC = No changes.
↑ or ↓ = Increased or decreased values compared to baseline (D-35) control.

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