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Table 3 Modulation of the immune parameters in the MSC-kidney transplantation recipients

From: Intra-osseous injection of donor mesenchymal stem cell (MSC) into the bone marrow in living donor kidney transplantation; a pilot study

No Age/Sex Clinical outcome at 12 Month Tregs1 Donor-specific lymphocyte proliferation2 Donor-specific T cell proliferation3 Cytokines4
1 34/M Borderline change ↑↑ - IL-10 at D + 7 IL-6 at D + 7
2 48/F No AR ↑↑ - - IL-10 at D + 30
3 40/M No AR - ND* ND* NC**
4 32/F ACR - ↑↑ NC**
5 36/M No AR - ↓↓ ↓↓ IL-6 at D + 7 IFN-γ at D + 30
6 36/F Borderline change - - -  
7 40/F ACR - ↓↓ IFN-γ at D + 4
  1. 1Represented by the level of FoxP3mRNA : compared to baseline (D −35) control (Figure 1).
  2. 2Peripheral blood lymphocytes were co-cultured with donor cells (MLR) (Figure 2).
  3. 3ConA-induced T cell proliferation in the MLR system. (Figure 3).
  4. 4Cytokines their secretion was significantly increased compared to donor and baseline (D-35) level. (Figures 4, 5, 6).
  5. *ND = Not detected: due to the lack of sample.
  6. **NC = No changes.
  7. ↑ or ↓ = Increased or decreased values compared to baseline (D-35) control.