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Table 1 Data elements

From: Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology

Participant

Age (years)

Race/ Ethnicity

Income range

Employment/Disability status

BMI

Mode of onset

Duration of illness (years)

Fatigue severity (0=none, 100=severe)

Muscle pain severity (0=none, 100=severe)

Joint pain severity (0=none, 100=severe)

Sleep quality (0=poor, 100=good)

Multi-dimensional fatigue inventory MFI-20§

Fatigue severity scale§

HADS: Depression Sub-score

Meets FM criteria

Co-morbid conditions

Medications

1

54

Caucasian

$10,000-19,999

Not reported

18

Acute

35

61

50

46

39

88

6.67

6

Yes

Osteoarthritis

Aspirin, Levothyroxine

2

53

Caucasian

$20,000-29,999

Retired/Disablility

31.6

Acute

15

73

71

70

52

96

6.78

13

Yes

Hypothyroid, High Blood Pressure

Alprazolam, Amlodipine, Levothyroxine, Valganciclovir†, Naproxen, Melatonin, Aspirin, Estradiol

3

53

Caucasian

Not reported

Retired

25.2

Gradual

30

80

60

41

65

76

6.56

6

Yes

Degenerate Arthritis, Spinal Stenosis, Sleep Apnea

Estradiol, Valganciclovir†, Lidocaine

4

47

Caucasian

less than $10,000

Unemployed

25.9

Acute

9

31

6

50

41

81

6.67

3

Yes

High Cycling EBV and HHV-6, Chronic Sinus Infections, Chlamidophila Pneumonia

Loratadine, Cetirizine, Hydroxyzine, Diphenhydram, Gabapentin, 5- Hydroxytryptophan, St. John's Wort

5

61

Caucasian

$10,000-19,999

Unemployed/Disability

35.7

Gradual

7

50

33

32

37

94

7.00

10

No

Graves Disease/Hypothyroid, Obesity

Bupropion, Estradiol, Fenofibrate, Levothyroxine, Valganciclovir†, Fluoxetine, Acetaminophen

6

60

Caucasian

$80,000 or more

Employed

20.6

Gradual

5

64

49

42

39

90

5.89

11

Yes

None

None

7

51

Caucasian

$10,000-19,999

Disability

23.3

Gradual

5

81

25

0

71

89

5.89

3

Yes

None

Acyclovir††

8

29

Caucasian

$40,000-49,999

Employed

27.5

Gradual

15

62

63

67

55

NA

NA

0

Yes

None

Topiramate

9

55

Caucasian

$60,000-69,999

Retired/Disablility

20.4

Acute

10

74

70

48

55

NA

NA

14

Yes

None

Bupropion, Controlled-Release Morphine, Progesterone, Loratadine, Diazepam, Alprazolam, Estradiol, Sertraline, Zolpidem, Rizatriptan, Ibuprofen, Ketorolac

10

62

Caucasian

$30,000-39,99

Not reported

42

Gradual

20

36

25

8

44

84

6.56

3

No

Hypothyroid, Obesity, High Blood Pressure, ADHD

Olmesartan, Bupropion, Thyroid, Estradiol, Dextroamphetamine and Amphetamine

11

57

Caucasian

$20,000-29,999

Employed

33.1

NA

NA

0

0

0

71

42

2.22

0

No

High Blood Pressure

Amlodipine, Asprin

12

48

Caucasian

less than $10,000

Unemployed

23

NA

NA

18

23

4

70

NA

NA

1

No

None

None

13

51

Caucasian

less than $10,000

Employed

21.3

NA

NA

30

7

19

54

NA

NA

2

No

None

Prozac

14

58

Caucasian

less than $10,000

Employed

25.1

NA

NA

0

0

0

67

NA

NA

3

No

None

None

15

52

Asian

Not reported

Employed

19.7

NA

NA

6

1

0

64

48

1.88

0

No

None

Proton Pump Inhibitor

16

50

Caucasian

$50,000-59,999

Employed

20.5

NA

NA

0

0

0

96

20

1.22

0

No

None

None

17

44

Caucasian

$30,000-39,999

Employed

25.5

NA

NA

5

12

0

77

25

1.77

1

No

None

None

18

47

African American

$80,000 or more

Employed

31.6

NA

NA

19

9

1

80

28

1.66

2

No

Borderline High Blood Pressure, High Cholesterol

Zyrtec

19

61

Caucasian

$40,000-49,999

Retired

24

NA

NA

15

0

0

79

26

1.77

1

No

Plantar Fasciitis

Loratadine

20

62

Latina

$10,000-19,999

Employed

24.5

NA

NA

6

5

0

79

22

1.33

1

No

None

None

  1. Data elements for each of the 20 participants (CFS: #1 – 10, Controls: #11 – 20). Participants self-reported race/ethnicity, income, employment/disability status, height, weight, mode of CFS onset, duration of CFS, co-morbid conditions, and medications. Fatigue, muscle pain, joint pain, and sleep quality were determined by taking the mean from the two-week baseline period of symptom severity assessments. The HADS [14] and Fibromyalgia Assessment Form [15] were administered during the screening visit. §Scores are from an existing database maintained by Stanford’s CFS Research Team. †Valganciclovir was prescribed as an experimental treatment for CFS, ††Acyclovir was prescribed for HSV-1 and HSV-2. NA = Not Available.