HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

Table 1 Patient characteristics

ID	Age			Primary tumor				Recurrence
	Diagnosis	Recurrence	Inclusion	Type	FIGO stage	Treatment	Chemotherapy	Region	Interval prim-rec (months)	Treatment	Chemotype	Interval Chemo-1st Vac (months)
1	40	41	41	cervix	IB1	RH/CHRT	Cisplatin	LR	14			12.0
2	49	51	51	cervix	IIB	CHRT	Cisplatin	D	26			33.3
3	43	46	46	cervix	IB1	RH/RT		D	37
4	34	35	36	cervix	IB2	CHRT/RH	Cisplatin	D	18			17.1
5	30	30	30	cervix	IB1	RH/CHRT	Cisplatin	LR	6			5.3
6	55	56	56	cervix	IIIB	CHRT	UK	D	3			3.9
7	51	52	53	vagina	IVB	CHRT	Carboplatin/Taxol	D	16	RT		19.6
8	34	36	36	cervix	IB1	RH/RT		D	19	CH	Cisplatin/Topotecan	1.8
9	54	56	56	vagina	IIB	CHRT	Cisplatin	D	20	RT + HT		22.9
10	38	45	46	anus		CHRT	UK	LR	79	CHRT	UK	41.9
11	44	46	46	cervix	IIIB	CHRT	Cisplatin	D	6			4.9
12	36	40	41	cervix	IIA	RH/CHRT	Cisplatin	D	40	HT + CH	Carboplatin/Taxol	4.4
13	62	63	63	cervix	IV	RH/CHRT	Cisplatin	D	11			7.9
14	32	32	32	cervix	IIB	CHRT	Cisplatin	D	8			7.5
15	35	36	36	cervix	IB1	SN/CHRT	Cisplatin	LR	4	SUR		4.3
16	54	54	54	cervix	IV
17	48	49	50	cervix	IIB	SUR		D	9
18	58	59	59	cervix	IB2	CHRT/RH	Cisplatin	D	11	RT
19	52	54	54	cervix	IIA	CHRT	Carboplatin/Cisplatin	LR	31			37.4
20	39	40	41	cervix	IB1	RH		D	14	CHRT + CH	Carboplatin/Taxol	2.2
21	46	47	47	anus		CH	Cisplatin/Vinorelbine		4			6.5

LR, locoregional; D, distant metastasis; RH, radical hysterectomy; CH, chemotherapy; CHRT, chemoradiation; RT, radiotherapy; SN, Sentinal Node Procedure; HT, hyperthermia; SUR, surgery; UK, unknown; FIGO, International Federation of Gynecologists and Obstetricians. FIGO stage IB1 (clinical lesion ≤ 4 cm) and IB2 (clinical lesion > 4 cm) confined to the cervix. Stage II: tumor extension beyond the cervix, but not the distal 1/3 part of the vagina or the pelvic wall (stage IIA: involvement of the proximal 2/3 part of the vagina, stage IIB: parametrial involvement). Stage IIIB, carcinoma has extended to the pelvic wall and/or the distal 1/3 part of the vagina, and/or causes hydronefrosis. Stage IV, carcinomas spread to the mucosa of the bladder or rectum (stage IV A) or distant organs (stage IVB). The interval between the primary tumor and recurrence (prim-rec) is given in months. The interval between the chemotherapy and the 1^st vaccination (Chemo-1st Vac) was calculated by using the starting date of the last given chemotherapy and the date of first vaccination as reference points.

ISSN: 1479-5876