From: Cardioprotective effects of lixisenatide in rat myocardial ischemia-reperfusion injury studies
 | Sham | I/R Placebo | I/R ramipril (1 mg/kg/d p.o.) | I/R lixisenatide (10 μg/kg/d s.c.) |
---|---|---|---|---|
Body Weight (g) | 441 ± 9 | 432 ± 9 | 403 ± 7* | 390 ± 6* |
Food consumption (mg/kg/d) | 73 ± 3 | 78 ± 2 | 72 ± 5 | 79 ± 4 |
Water consumption (mL/kg/d) | 116 ± 3 | 120 ± 2 | 168 ± 5* | 120 ± 2 |
Plasma BNP (pg/mL) | 112 ± 5* | 178 ± 14 | 113 ± 6* | 110 ± 7* |
Plasma glucose (mmol/L) | 8.8 ± 0.2 | 8.8 ±0.3 | 8.6 ± 0.3 | 8.0 ± 0.4 |
Plasma triglyceride (mmol/L) | 0.61 ± 0.09 | 0.49 ± 0.05 | 0.44 ± 0.04 | 0.47 ± 0.03 |
Plasma ACE activity [U/L] | 186 ± 17 | 206 ± 37 | 51 ± 11* | 192 ± 10 |
LVP (mmHg) | 118 ± 5* | 106 ± 3 | 97 ± 2* | 105 ± 3 |
LVedP (mmHg) | 3.22 ± 0.49* | 10.32 ± 1.45 | 5.11 ± 0.93* | 4.52 ± 0.43* |
dP/dt max (mmHg/sec) | 6695 ± 268* | 5023 ± 210 | 4724 ± 197 | 5136 ± 243 |
dP/dt min (mmHg/sec) | −6877 ± 373* | −4463 ± 206 | −4499 ± 184 | −4683 ± 278 |
Heart Rate (beats/min) | 324 ± 8 | 316 ± 6 | 327 ± 7 | 308 ± 8 |
tau Weiss (msec) | 8.39 ± 0.45* | 15.08 ± 0.75 | 11.93 ± 0.76* | 11.37 ± 0.47* |
Heart Weight (g/100 g BW) | 0.26 ± 0.01* | 0.29 ± 0.01 | 0.28 ± 0.01 | 0.28 ± 0.01 |
Cardiac expansion index | 0.29 ± 0.02 | 0.28 ± 0.04 | 0.23 ± 0.05 | 0.30 ± 0.05 |
Lung Weight (g/100 g BW) | 0.44 ± 0.03* | 0.63 ± 0.05 | 0.44 ± 0.02* | 0.43 ± 0.02* |
Liver Weight (g/100 g BW) | 3.31 ± 0.04 | 3.23 ± 0.06 | 3.12 ± 0.05 | 3.02 ± 0.16 |
Right Kidney Weight (g/100 g BW) | 0.30 ± 0.01 | 0.30 ± 0.01 | 0.35 ± 0.01* | 0.30 ± 0.01 |