Figure 3

Effect of long-term treatment with either lixisenatide or ramipril after transient ischemia-reperfusion injury on heart morphology. (A) Picrosirius red staining at the papillary muscle level of representative animals, Bar = 5 mm; (B) quantification of left ventricular fibrotic to total area; (C) thickness of the left ventricular, septal and right ventricular wall; and (D) gene expression analysis by realtime PCR of selected fibrosis genes. ^*) denotes p < 0.05 versus sham and ^#) p < 0.05 versus placebo.