Table 3 GLV-1h68 susceptibility in cell culture and in vivo of CRC cell lines derived from different clinical stages
Cell line | Clinical stage | GLV-1h68 replication in culture | GLV-1h68 cytotoxicity in culture | GLV-1h68 treatment in xenograft models |
|---|---|---|---|---|
HCT-116 | Duke’s type A | fast | high | growth inhibition |
HT-29 | Duke’s type B | fast | high | non-responder |
SW-620 | Duke’s type C | slow | medium | growth inhibition |
HCT-15 | Duke’s type C | medium | low | non-responder |
Colo 205 | Duke’s type D | fast | high | n.d. |