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Table 1 Viral titers in mouse tissues or tumors

From: Growth inhibition of different human colorectal cancer xenografts after a single intravenous injection of oncolytic vaccinia virus GLV-1h68

Viral Titers (mean ± standard deviation)[pfu/g]

Tissue

3 dpi

#

14 dpi

#

tumor

2.94 × 105 ± 5.54 × 105

5/5

4.21 × 107 ± 2.48 × 107

5/5

lungs

4.21 ± 6.11

1/5

2.62 ± 3.59

2/5

liver

n.d.

0/5

3.88 ± 8.68

1/5

spleen

n.d.

0/5

n.d.

0/5

kidney

n.d.

0/5

n.d.

0/5

testes

n.d.

0/5

n.d.

0/5

  1. The viral titers in mouse tissues or tumors are shown. HCT-116-bearing mice [n=5] were sacrificed 3 days or 14 days [dpi] after i.v. injection of 5x106 pfu GLV-1h68. Tissues and tumors were surgically excised, homogenized and viral titers were determined by standard plaque assay. Titers are displayed as means of all animals sacrificed per time point and in # column of the table indicates the number of positively tested animals out of all the tested animals in the group. n.d. = not detected.
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Journal of Translational Medicine

ISSN: 1479-5876

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