Figure 7

Virus-mediated Ruc -GFP expression at the local tumor site of HCT-116-bearing mice. A) Analysis of GFP fluorescence intensity in GLV-1h68-treated mice during the course of the experiment. GFP intensity is determined by using a four level visual scoring system; 0) no GFP signal, 1) one spot, 2) two or three local spots, 3) diffuse signal from half the tumor, 4) strong signal from whole tumor. Average scores with standard errors for groups of five mice at each time point are presented. B) Fluorescence imaging of GFP expression at the local tumor site is shown for one representative mouse.