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Table 1 Basal levels of pS6 in MM tumor and immune cells

From: Development of a robust flow cytometry-based pharmacodynamic assay to detect phospho-protein signals for phosphatidylinositol 3-kinase inhibitors in multiple myeloma

Cell type CD marker Location pS6 PD response
Tumor cells CD45-; CD38+; CD138+ BMA +++ Robust
Monocytes CD45+; CD14+ PB, BMA +++ Moderate
B cells CD45+; CD20+ PB, BMA - N/A
T cells CD45+; CD3+ PB, BMA - N/A