Expression of immune-related genes during ipilimumab treatment. (A) Functional interpretation of genes differentially expressed between baseline and week 11, as computed by Ingenuity Pathway Analysis (IPA) software (Ingenuity Systems). The P value reflects the significance of the enrichment of input genes in the functional category or pathway of interest. For every canonical pathway, IPA also provides the ratio of the number of genes from the input list that are annotated to the pathway to the total number of genes annotated to the pathway. (B) Fold change over time in expression of immunoglobulin-associated genes in the GI irAE and No-GI irAE groups. Genes shown were selected from the top 50 genes having the most prominent mean differences in on-treatment expression between the two GI irAE groups.