Figure 1

CD177 expression during ipilimumab treatment. (A) Mean expression of CD177 during ipilimumab treatment in patients who experienced grade 2+ gastrointestinal immune-related adverse events (GI irAE), or did not (No-GI irAE). Mean gene expression in patients showing clinical activity (CA) or not (No-CA) also are plotted; (B) Mean expression of CD177 during ipilimumab treatment in patients who experienced grade 2+ GI irAE, or did not (No-GI irAE), and mean absolute peripheral blood neutrophil counts (APBNC) during the same time period, by worst-grade GI irAE (bars); (C) CD177 expression level (RMA-normalized value) versus worst-grade GI irAE, by sample-collection time; (D) CD177 expression level (anti-log RMA-normalized value) at week 3 versus time to onset of first grade 2+ GI irAE. Numbers in the circles describe the worst grade of GI irAE reported during the course of treatment. Highlighted circle represents CD177 expression in the patient who experienced a fatal grade-4 GI irAE.