From: Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6- and glutathione-dependent mechanism
Lung metastases
B16-F10
B16-F10/IL-6-siRNA
Tumor IL-6 expression (-fold change)
1.0 ± 0.2
0.15 ± 0.05*
Serum IL-6 (pg/ml)
347 ± 75
132 ± 34*
Hypothalamic CRH expression (AU)
40 ± 12
85 ± 16*
Plasma ACTH (pg/ml)
240 ± 50
255 ± 63