Figure 4
From: Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases
LIGHT expression is decreased in CD3+ and CD4+ intratumoral lymphocytes. A. Representative flow cytometry histogram of LIGHT expression in different T cell subsets. B. Summary of flow cytometry analysis of T cells from tumor tissues reveals decreased LIGHT expression on CD3+ and CD4+ lymphocytes. Twenty-one percent of control liver CD3+ cells were LIGHT + compared to 10.1% in CRLM (p = 0.017, n=7 per group). Similarly, 29% of control liver CD4+ cells were LIGHT + compared to 16.5% in CRLM (p = 0.007, n=3 per group).