Significantly fewer protein functional changing variants for lipid metabolism in Africans than in Europeans

Table 4 Statistic results of permutation test for the difference of mean R in carbohydrate, lipid and amino acid metabolism between African and European (or Asian) with the consideration of background level in 1000 Genome data ^a

Index	Metabolism	Energy materials	1000 Genome data
			African *Vs.* European		African *Vs.* Asian
			R'_{African-European}	*P-value*	R'_{African-Asian}	*P-value*
R	Energy expenditure (Catabolic process)	Carbohydrates	-0.2307	0.0535	2.947	0.4925
		Lipids	0.5753	0.072	1.93	0.099
		Amino acids	0.8928	0.3275	0.545	0.111
	Energy storage (Biosynthetic process)	Carbohydrates	3.642	0.718	3.066	0.324
		Lipids	1.798	0.0385*	11.25	0.797
		Amino acids	4.236	0.213	9.857	0.6485
Num	Energy expenditure (Catabolic process)	Carbohydrates	0.6644	0.12	8.45	0.5425
		Lipids	-0.865	0.03*	1.24	0.0115*
		Amino acids	3.516	0.483	1.34	0.0975
	Energy storage (Biosynthetic process)	Carbohydrates	9.85	0.735	7.43	0.2535
		Lipids	4.857	0.048*	30.45	0.865
		Amino acids	6.0	0.0725	21.93	0.3775

^a R’ is the difference of mean genetic risk in carbohydrate, lipid and amino acid metabolism between African and European (or Asian); P-value is P_{(R’<R’African-European)} for the test for the difference between African and European, which means the probability of the difference (R’) between African and European in permutation test being smaller than the difference observed in a given metabolic process.
* means P-Value<0.05.

ISSN: 1479-5876