Figure 5

Cycle-dependent antitumor activity of L-BLP25. In the single-cycle study (A), male MUC1.Tg mice were given one cycle of eight weekly doses of L-BLP25 starting immediately following urethane induction and then followed for 20 additional weeks. In the two-cycle study (B), MUC1.Tg mice were given an additional cycle of L-BLP25 starting 11 weeks after the end of the first cycle and continuing weekly until the conclusion of the study in Week 41. The only statistically significant difference in number of tumor foci (p < 0.01) was observed between the untreated and CPA + L-BLP25 groups following two cycles of L-BLP25 (B). In both studies, CPA was administered three days prior to the start of each cycle of L-BLP25. Data are shown as average number of tumor foci + standard deviation.