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Table 2 Baseline and evoked inflammatory biomarker responses to endotoxemia

From: Race and gender variation in response to evoked inflammation

 

Male EA N=102

Male AA N=41

Female EA N=91

Female AA N=60

Race

Gender

 

Median (IQR)

Median (IQR)

Median (IQR)

Median (IQR)

P value*

P value*

TNFα (pg/mL) Baseline

1.08 (0.6)

1.03 (0.6)

1.06 (0.6)

1.13 (0.9)

0.64

0.66

Peak

43.5 (44)

37.3 (34)

43.2 (66)

34.0 (39)

0.42

0.55

AUC

156.7 (152)

123.4 (117)

151.4 (215)

116.4 (124)

0.18

0.12

IL-6 (pg/mL) Baseline

1.9 (2.1)

2.3 (2)

2.3 (1.7)

2.9 (2.2)

0.0013

0.0047

Peak

138.3 (158)

127.0 (134)

162.6 (195)

143.7 (149)

0.89

0.08

AUC

403 (403)

299 (362)

414 (410)

364 (300)

0.51

0.36

IL-1RA (pg/ml) Baseline

106.9 (53)

91.4 (55)

121.0 (64)

121.6 (67)

0.64

<0.0001

Peak

42843 (41293)

27676 (43350)

44073 (50058)

29789 (35435)

0.002

0.89

AUC

133260 (127732)

88663 (131287)

136600 (144853)

87536 (97476)

0.0007

0.96

CRP (mg/L) Baseline

0.34 (0.6)

0.54 (0.9)

0.62 (1.4)

0.71 (1.7)

0.40

0.11

Peak

17.8 (13)

14.3 (11)

15.9 (12)

10.8 (8.3)

0.005

0.12

AUC

196 (111)

164 (107)

171 (116)

127 (84)

0.002

0.02

SAA (mg/L) Baseline

2.8 (0.2)

2.8 (0.6)

2.8 (2.3)

2.8 (1.6)

0.48

0.25

Peak

91.0 (53)

74.4 (62)

80.7 (51)

57.7 (58)

0.16

0.02

AUC

1073 (602)

858 (710)

939 (582)

773 (572)

0.03

0.04

  1. TNFα, Tumor necrosis Factor alpha; IL-6, Interleukin 6; IL-1RA, Interleukin 1 receptor agonist; CRP, C-reactive protein; SAA, Serum Amyloid A; AUC, area under the curve, calculated using the trapezoidal rule. *P values are from linear regression models run on log-transformed variables for non-normally distributed variables. Models adjusted for Age and Waist:Hip ratio (WHR).