Figure 4

Longitudinal cell-mediated and antibody responses to LTB. a) Frequencies of LTB-specific IFN-γ producing T cells from evaluable subjects in both Studies 1 and 2, who had received low- or high-dose V930 DNA-EP vaccination. Arrow shows day of last V930-DNA-EP vaccination. Differences in peak values (day 87) from baseline levels were statistically significant for anti-LTB antibody responses (*P=0.03 by Wilcoxon rank sum test). b) Anti-LTB antibody responses. Differences in peak values (day 87) from baseline levels were statistically significant for the high-dose cohort (P<0.007 by Wilcoxon rank sum test). Peak levels (day 72) for the low-dose cohort were not significantly different from baseline levels (P>0.05).