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Table 1 Differences between immunoscore and immunoprofiling

From: The additional facet of immunoscore: immunoprofiling as a possible predictive tool for cancer treatment

 

Immunoscore

Immunoprofiling

 

Prognostic/Predictive(?)

Prognostic/Predictive(?)

Number of immune markers

2-4

1 – Several

Immunoscore markers

CD3/CD8

 

Immunoscore-like markers

CD3/CD8/CD20/FoxP3

Immune gene signatures

 

CD3/CD8/CD45RO

Multiplex assays

 

CD4/CD8/CD68

CD137, Galectin1, LAG-3, OX40, PD-

 

CD3/CD8/CD20, CD3/GZMB

 
 

CD8/FoxP3

 
 

CD8/IL17

 
 

(others)

 

Possible application

• Staging in colorectal cancer (already tested)

• Prognostic assay

 

• Staging in Melanoma, Breast cancer, Ovarian cancer, NSCLC, Prostate cancer, Pancreatic cancer, Head & Neck cancer (to be defined).

• Predictive assay

  

• Personalized immune-treatment