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Table 1 Characteristics of the study population and analysis of the demographic characteristics and HIV-related parameters between low bone mineral density (LBMD) patients (T-score < -1) and normal bone mineral density (NBMD) patients (T-score ≥ -1)

From: Association between peripheral T-Lymphocyte activation and impaired bone mineral density in HIV-infected patients

 

TOTAL (n = 78)

LBMD (n = 55)

NBMD (n = 23)

P§

Demographic characteristics

    

male

68%

66.7%

69.6%

0.80*

mean age (IC 95%)

46 (43–48)

46 (43–48)

45 (40–50)

0.81

mean BMI (IC 95%)

23.4 (22.5-24.3)

23.4 (22.5-24.9)

24.6 (23.0-26.2)

0.16

HIV-related parameters

    

AIDS diagnosis

22%

23%

17%

0.54*

time from HIV diagnosis (IC 95%)

7.8 years (6.3-9.3)

7.8 years (5.8-9.8)

7.8 years (5.5-10.4)

0.99

mean CD4 nadir (IC 95%)

268 cell/mm3 (226–310)

266 cell/mm3 (214–317)

265 cell/mm3 (195–336)

0.98

mean current CD4 (IC 95%)

507 cell/mm3 (437–577)

490 cell/mm3 (400–579)

512 cell/mm3 (407–617)

0.77

mean CD4/CD8 ratio (IC 95%)

0.7 (0.59-0.80)

0.7 (0.54-0.77)

0.8 (0.56-1.02)

0.25

co-infection with viral hepatitis

    

HCV Ab positivity

10%

12%

4%

0.26**

HBsAg positivity

5%

3%

8%

0.63**

naïve patients

26%

28%

17%

0.31**

mean time of HAART exposure (IC 95%)

4.6 years (3.4-5.9)

4.0 years (2.6-5.5)

6.2 years (3.8-8.7)

0.13

type of HAART

   

0.40*

TDF-based backbone

53%

54%

53%

 

PI-based

33%

34%

35%

 

NNRTI-based

37%

33%

48%

 

undetectable viremia (HIV-RNA <40 UI/mL) (in patients on HAART)

92%

88%

94%

1.00*

  1. §p, comparison between LBMD and NBMD patients by *Pearson’s chi-squared test and **Fisher’s exact test.