Figure 2

The immune senescent pattern of CD4+ and CD8+ T-cells. Patients with LBMD are shown in the circles, and patients with NBMD are shown in the triangles. The bars correspond to the IQR. A) The median percentage of CD28+ and CD28-CD4+ T-cells. B) The median percentage of CD28+ and CD28-CD8+ T-cells. C) The median percentage of CD4+ T-cell sub-populations as defined by CD28 and CD57 co-expression (CD28 + CD57-, CD28 + CD57+, CD28-CD57-, and CD28-CD57+). D) and E) are representative plots that show the senescence markers (CD57 and CD28) on the CD4+ T-cells of patients with LBMD (D) and patients with NBMD (E). The data were compensated and analyzed using CXP 2.2 software (Beckman-Coulter). F) The median percentage of CD8+ T-cell sub-populations as defined by CD28 and CD57 co-expression (CD28 + CD57-, CD28 + CD57+, CD28-CD57-, and CD28-CD57+). G) and H) are representative plots that show the senescence markers (CD57 and CD28) on the CD8+ T-cells of patients with LBMD (G) and patients with NBMD (H). The data were compensated and analyzed using CXP 2.2 software (Beckman-Coulter).