Figure 1From: Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumorStructure of anti-KIT chimeric immune receptor. (A) Schematic diagram of 1st and 2nd generation CIR genetic constructs. (B) Structure of 1st and 2nd generation CIR. Anti-KIT CIRs were re-engineered from anti-CEA retroviral vector constructs, whereby the extracellular domain of kit ligand (KL) was amplified and cloned to replace the anti-CEA extracellular domain.Back to article page