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Figure 3 | Journal of Translational Medicine

Figure 3

From: Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling

Figure 3

Increased survival in Tgfbr1/Pten 2cKO mice dosed with IL-13-PE. (A) A schematic showing the dosing schedule of IL-13-PE to Tgfbr1/Pten 2cKO mice. (B) Survival curve shows increased longevity in Tgfbr1/Pten 2cKO mice treated with IL-13-PE (measured in days following tumor induction). Median survival increased from 69 days in the controls to 92 days with IL-13-PE treatment (P value = 0.002 Log-rank [Mantel-Cox] Test). (C) The treated mice continue gaining weight after IL-13-PE therapy as compared to the control mice (P value < 0.0001 Two-way ANOVA).

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