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Figure 1 | Journal of Translational Medicine

Figure 1

From: Targeting of interleukin-13 receptor α2 for treatment of head and neck squamous cell carcinoma induced by conditional deletion of TGF-β and PTEN signaling

Figure 1

Upregulation of IL-13Rα2 in tumors from Tgfbr1/Pten 2cKO mice. (A) Western blot analysis showing upregulation of IL-13Rα2 in multiple squamous cell carcinomas (SCC) which develop from loss of Tgfbr1/Pten in the head and neck epithelium. Tumors can be identified by increases in both p-Akt, genetically induced with Pten deletion, and in p-Stat3, a commonly activated signaling pathway in HNSCC. (B) Positive immunohistochemical analysis showing IL-13Rα2 staining on two representative SCCs as compared to the normal tongue epithelium. (C) Real-time PCR shows increases in mRNA of all IL-13 receptor subunits between three pairs of tongue tumors and the normal tongue tissue (P value < 0.0001 in most cases).

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