Effects of P276-00 on CCND1/pRB mediated E2F1 pathway in FaDu xenograft model. a) RTQPCR based mRNA profiling of E2F1 downstream targets using tumor from HNSCC (FaDu) xenograft model. Data is represented at log2 scale mean ± S.E.M. (n = 3–4). (b) Representative images from immunohistochemical analysis of various proteins in FaDu xenograft tumors- P276-00 treated mice (right) or vehicle (left), (c) graphical representation of immunohistological score.