P276-00 inhibit growth signaling proteins and cytokine in FaDu cells. (a-b) P276-00 inhibits mRNA level of IL-6, EGFR and HSPA8 in FaDu cells. The relative expression level of these genes was measured in comparison with control sample (a) Time dependent response (b) dose response. (c-d) P276-00 potently suppresses in vitro production of IL-6 and HSPA8 in FaDu cells. (c) IL-6 (d) HSPA8. All values are average ± S.E.M. (n=3-5) * indicates p-val < = 0.05 as compared to DMSO pre-treated control cells.